I've gone from not knowing what I was playing (you know; those days before the internet and I just bought my JV Squier Strat because I wanted 'A Strat'). Then I found out about specs, such as radius, fret sizes and scale lengths and started trying to buy based on specs (or at least picking those models out to try in the shops). Kind of backed myself into a corner and ended up with a few very similar guitars, so I traded some in the end for more variety. Last year I pushed myself to buy a replacement Tele neck completely out of my usual range (slimmer neck, 7.25" radius and vintage frets) and put a 'Fat U 51' neck on a project, that has 9.5" radius and medium tall frets. I got used to it and it plays great. Then I found that what actually works for me is playing different guitars: I had started to get issues with my hands and in particular my little finger. I found that swapping between fat and thin necks, different radius (radii?) and even shorter scale such as a 24" Fender Jaguar seems to help. A change being as good as a rest (since sometimes I'd just have to not play for 3-4 days otherwise until my hand/finger recovered). On Monday I took 3 guitars to a jam night and since I don't know when we will be able to do it again I took 3 guitars: Fat neck Tele 25.5" 9.5" radius tall frets. 60s slim taper Gibson Les Paul 24.75" scale, 12" radius medium jumbo frets that I had levelled and crowned. Medium C shaped Fender Jaguar 24" scale, 9.5" radius vintage tall frets. (Deduct points for not taking my Strat, but I hadn't got round to restringing it for a while).